Scientists Reverse Alzheimer's Brain Loss in Fruit Flies

RedTracker| Alzheimer’s researchers have succeeded in preventing memory loss in fruit flies caused by brain plaques similar to those in human brains suffering from the disease. The study also resolves long-standing controversy about the role of P13 kinase, a protein previously thought to have a protective function against the disease. Now the increased activity of P13 is considered a catalyst in the degeneration of brains in Alzheimer’s patients.

A reduction of this activity via injections of PI3 kinase-blocking drugs or by switching off the gene that encodes PI3 kinase both restored normal LTD signals. With these measures, the team not only improved memory in aging fruit flies, but also decreased the buildup of β-amyloid deposits. via Science Daily